Read e-book online Advances in Swine in Biomedical Research: Volume 2 PDF

By Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)

ISBN-10: 1461376998

ISBN-13: 9781461376996

ISBN-10: 1461558859

ISBN-13: 9781461558859

Similarities in constitution and serve as among pigs and people comprise dimension, feeding styles, digestive body structure, nutritional conduct, kidney constitution and serve as, pulmo­ nary vascular mattress constitution, coronary artery distribution, propensity to weight problems, respiration premiums, tidal volumes and social behaviors. because the pig is an omnivore, it presents an adaptable version to guage continual and acute exposures to xenobiotics corresponding to alcohoL caffeine, tobacco, meals ingredients and environmental toxins. Swine were used effectively as types to judge alcoholism, diabetes, absorption, digestion, overall paren­ teral nutrients, organ transplantation, atherosclerosis, workout, high blood pressure. hemorrhagic hypotension, cancer, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal therapeutic and septic surprise. A critical and irritating scarcity of organs and tissues for transplantation in sufferers with critical organ failure has inspired the glory of inter species or xenotransplan­ tation. In constructing courses towards this finish, the pig mostly is considered because the hottest donor due to its dimension, body structure and availability. The pig harbors fairly few illnesses that may be transmitted inadvertently to human sufferers. the power to genetically regulate swine to ameliorate the results of the human immune reaction deals one more major virtue. one other very important attention for an animal version is that uncomplicated biologic again­ flooring info be to be had for investigators to layout destiny potential studies.

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Extra resources for Advances in Swine in Biomedical Research: Volume 2

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Res. 9: 1422-1427. 17. Pharm. Sci. 81:601-602. 18. , 1982, Percutaneous absorption and anti-inflammatory activity of indomethacin in ointment, J. Pharm. Pharmacol. 34:467468. 19. , 1988, Anti-inflammatory activity of piroxicam after oral and topical administration on an ultraviolet-induced erythema model in man, Curr. Ther. Res. 44:340-347. 20. , 1983, Drug delivery to local subcutaneous structures following topical administration,}. Pharm. Sci. 72: 1375-1380. 21. , 1992, Determination oflidocaine concentrations in skin after transdermal iontophoresis: Effects of vasoactive drugs, Pharm.

Using a radiolabeled vesicant, we were able to show a correlation between the incidence of penetration of radiolabel through excised pig skin and the occurrence of skin irritation/inflammation in vivo. With the addition of data for other compounds and vehicles, it will be possible to develop a general model for assessing skin absorption and irritation potential. 2. INTRODUCTION Insecticides and solvents are familiar examples of volatile substances which come in contact with the skin. Mechanical removal, evaporation and penetration are key processes which contribute to the removal of these substances from the skin surface.

Pathal. 121 :28-38. 105. , 1987, Inflammatory mediators and modulators released in organ culture from rabbit skin lesions produced in vivo by sulfur mustard. III. Electrophoretic protein fractions, trypsin-inhibitory capacity, I-proteinase inhibitor, and 1- and 2- macroglobulin proteinase inhibitors of culture fluids and serum, Am. 1. Pathol. 126: 148-163. 458 N. A. Monteiro-Riviere and J. Riviere 106. , 1988, Proteases released in organ culture by acute dermal inflammatory lesions produced in vivo in rabbit skin by sulfur mustard: Hydrolysis of synthetic peptide substrates for trypsin-like and chymotrypsin-like enzymes, Inflammation 12:311-334.

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Advances in Swine in Biomedical Research: Volume 2 by Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)


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